Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/15347
Title: Characteristics of drug-resistant tuberculosis in Abkhazia (Georgia), a high-prevalence area in Eastern Europe.
Authors: Pardini, M
Niemann, S
Varaine, F
Iona, E
Meacci, F
Orrù, G
Yesilkaya, H
Jarosz, T
Andrew, P
Barer, M
Checchi, F
Rinder, H
Orefici, G
Rüsch-Gerdes, S
Fattorini, L
Oggioni, MR
Bonnet, M
First Published: Jul-2009
Citation: TUBERCULOSIS (EDINB), 2009, 89 (4), pp. 317-324
Abstract: Although multidrug-resistant (MDR) tuberculosis (TB) is a major public health problem in Eastern Europe, the factors contributing to emergence, spread and containment of MDR-TB are not well defined. Here, we analysed the characteristics of drug-resistant TB in a cross-sectional study in Abkhazia (Georgia) between 2003 and 2005, where standard short-course chemotherapy is supplemented with individualized drug-resistance therapy. Drug susceptibility testing (DST) and molecular typing were carried out for Mycobacterium tuberculosis complex strains from consecutive smear-positive TB patients. Out of 366 patients, 60.4% were resistant to any first-line drugs and 21% had MDR-TB. Overall, 25% of all strains belong to the Beijing genotype, which was found to be strongly associated with the risk of MDR-TB (OR 25.9, 95% CI 10.2-66.0) and transmission (OR 2.8, 95% CI 1.6-5.0). One dominant MDR Beijing clone represents 23% of all MDR-TB cases. The level of MDR-TB did not decline during the study period, coinciding with increasing levels of MDR Beijing strains among previously treated cases. Standard chemotherapy plus individualized drug-resistance therapy, guided by conventional DST, might be not sufficient to control MDR-TB in Eastern Europe in light of the spread of "highly transmissible" MDR Beijing strains circulating in the community.
DOI Link: 10.1016/j.tube.2009.04.002
eISSN: 1873-281X
Links: http://hdl.handle.net/2381/15347
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Infection, Immunity and Inflammation

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