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Title: Linear motifs in the C-terminus of D. melanogaster cryptochrome.
Authors: Hemsley, MJ
Mazzotta, GM
Mason, M
Dissel, S
Toppo, S
Pagano, MA
Sandrelli, F
Meggio, F
Rosato, E
Costa, R
Tosatto, SC
First Published: 6-Apr-2007
Citation: BIOCHEM BIOPHYS RES COMMUN, 2007, 355 (2), pp. 531-537
Abstract: The C-terminus of cryptochrome (CRY) regulates light responses in Drosophila. These include the light-dependent binding of Drosophila dCRY to the clock proteins PERIOD and TIMELESS in a yeast two-hybrid system, which we proved to be a convenient and reliable readout of the behavior of dCRY in vivo. In this study, we present a combination of in silico analysis and experimental validation in yeast, to identify novel functional motifs in the C-terminal region of dCRY. Our results suggest that linear motifs are present in this small region, which is a likely hotspot for molecular interactions.
DOI Link: 10.1016/j.bbrc.2007.01.189
ISSN: 0006-291X
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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