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|Title:||Linear motifs in the C-terminus of D. melanogaster cryptochrome.|
|Citation:||BIOCHEM BIOPHYS RES COMMUN, 2007, 355 (2), pp. 531-537|
|Abstract:||The C-terminus of cryptochrome (CRY) regulates light responses in Drosophila. These include the light-dependent binding of Drosophila dCRY to the clock proteins PERIOD and TIMELESS in a yeast two-hybrid system, which we proved to be a convenient and reliable readout of the behavior of dCRY in vivo. In this study, we present a combination of in silico analysis and experimental validation in yeast, to identify novel functional motifs in the C-terminal region of dCRY. Our results suggest that linear motifs are present in this small region, which is a likely hotspot for molecular interactions.|
|Appears in Collections:||Published Articles, Dept. of Genetics|
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