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Title: Zymocin, a composite chitinase and tRNase killer toxin from yeast.
Authors: Jablonowski, D
Schaffrath, R
First Published: Dec-2007
Citation: BIOCHEM SOC TRANS, 2007, 35 (Pt 6), pp. 1533-1537
Abstract: Growth inhibition of Saccharomyces cerevisiae by the plasmid-encoded trimeric (alphabetagamma) zymocin toxin from dairy yeast, Kluyveromyces lactis, depends on a multistep response pathway in budding yeast. Following early processes that mediate cell-surface contact by the chitinase alpha-subunit of zymocin, later steps enable import of the gamma-toxin tRNase subunit and cleavage of target tRNAs that carry modified U34 (wobble uridine) bases. With the emergence of zymocin-like toxins, continued zymocin research is expected to yield new insights into the evolution of yeast pathosystems and their lethal modes of action.
DOI Link: 10.1042/BST0351533
ISSN: 0300-5127
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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