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|Title:||Zymocin, a composite chitinase and tRNase killer toxin from yeast.|
|Citation:||BIOCHEM SOC TRANS, 2007, 35 (Pt 6), pp. 1533-1537|
|Abstract:||Growth inhibition of Saccharomyces cerevisiae by the plasmid-encoded trimeric (alphabetagamma) zymocin toxin from dairy yeast, Kluyveromyces lactis, depends on a multistep response pathway in budding yeast. Following early processes that mediate cell-surface contact by the chitinase alpha-subunit of zymocin, later steps enable import of the gamma-toxin tRNase subunit and cleavage of target tRNAs that carry modified U34 (wobble uridine) bases. With the emergence of zymocin-like toxins, continued zymocin research is expected to yield new insights into the evolution of yeast pathosystems and their lethal modes of action.|
|Appears in Collections:||Published Articles, Dept. of Genetics|
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