Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/15380
Title: The combined effects of xeroderma pigmentosum C deficiency and mutagens on mutation rates in the mouse germ line.
Authors: Miccoli, L
Burr, KL
Hickenbotham, P
Friedberg, EC
Angulo, JF
Dubrova, YE
First Published: 15-May-2007
Citation: CANCER RES, 2007, 67 (10), pp. 4695-4699
Abstract: Spontaneous and induced mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germ line of xeroderma pigmentosum group C (Xpc) knockout mice defective in global genome nucleotide excision repair. Spontaneous and radiation-induced mutation rates in homozygous Xpc(-/-) males were significantly higher than those in isogenic wild-type (Xpc(+/+)) and heterozygous (Xpc(+/-)) mice. In contrast, exposure to the monofunctional alkylating agent ethylnitrosourea resulted in similar increases in ESTR mutation rates across all genotypes. ESTR mutation spectra in the germ line of Xpc(-/-), Xpc(+/-) and Xpc(+/+) did not differ. Considering these data and the results of other publications, we propose that the Xpc-deficient mice possess a mutator phenotype in their germ line and somatic tissues that may significantly enhance carcinogenesis across multiple tissues.
DOI Link: 10.1158/0008-5472.CAN-06-3844
ISSN: 0008-5472
Links: http://hdl.handle.net/2381/15380
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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