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|Title:||Elevated mutation rates in the germline of Polkappa mutant male mice.|
|Citation:||DNA REPAIR (AMST), 2006, 5 (7), pp. 860-862|
|Abstract:||Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of DNA polymerase kappa (Polkappa(-/-)) deficient mice. The spontaneous mutation rate in homozygous Polkappa(-/-) males was significantly higher than in isogenic wild-type mice (Polkappa(+/+)), but the ESTR mutation spectrum in Polkappa(-/-) animals did not differ from that in Polkappa(+/+) males. We suggest that compromised translesion synthesis in Polkappa(-/-) mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate.|
|Appears in Collections:||Published Articles, Dept. of Genetics|
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