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Title: Elevated mutation rates in the germline of Polkappa mutant male mice.
Authors: Burr, KL
Velasco-Miguel, S
Duvvuri, VS
McDaniel, LD
Friedberg, EC
Dubrova, YE
First Published: 13-Jul-2006
Citation: DNA REPAIR (AMST), 2006, 5 (7), pp. 860-862
Abstract: Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of DNA polymerase kappa (Polkappa(-/-)) deficient mice. The spontaneous mutation rate in homozygous Polkappa(-/-) males was significantly higher than in isogenic wild-type mice (Polkappa(+/+)), but the ESTR mutation spectrum in Polkappa(-/-) animals did not differ from that in Polkappa(+/+) males. We suggest that compromised translesion synthesis in Polkappa(-/-) mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate.
DOI Link: 10.1016/j.dnarep.2006.04.003
ISSN: 1568-7864
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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