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Title: Phenotypic effects induced by knock-down of the period clock gene in Bombyx mori.
Authors: Sandrelli, F
Cappellozza, S
Benna, C
Saviane, A
Mastella, A
Mazzotta, GM
Moreau, S
Pegoraro, M
Piccin, A
Zordan, MA
Cappellozza, L
Kyriacou, CP
Costa, R
First Published: Apr-2007
Citation: GENET RES, 2007, 89 (2), pp. 73-84
Abstract: The lepidopteran Bombyx mori is an insect of considerable scientific and economic importance. Recently, the B. mori circadian clock gene period has been molecularly characterized. We have transformed a B. mori strain with a construct encoding a period double-strand RNA in order to knock-down period gene expression. We observe that this post-transcriptional silencing produces a small but detectable disruption in the egg-hatching rhythm, as well as a reduction in egg-to-adult developmental time, without altering silk production parameters. Thus we show that both circadian and non-circadian phenotypes can be altered by changing per expression, and, at a practical level, these results suggest that per knock-down may provide a suitable strategy for improving the efficiency of rearing, without affecting silk productivity.
DOI Link: 10.1017/S0016672307008713
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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