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Title: Localized breakdown in linkage disequilibrium does not always predict sperm crossover hot spots in the human MHC class II region.
Authors: Kauppi, L
Stumpf, MP
Jeffreys, AJ
First Published: Jul-2005
Citation: GENOMICS, 2005, 86 (1), pp. 13-24
Abstract: To investigate the relationship between meiotic crossover hot spots and block-like linkage disequilibrium (LD), we have extended our high-resolution studies of the human MHC class II region to a 90-kb segment upstream of the HLA-DOA gene. LD blocks in this region are not as well defined as in the neighboring 210-kb DNA segment but do show two regions of LD breakdown in which coalescent analysis indicates substantial historical recombination. Sperm crossover analysis of one region revealed a novel localized hot spot similar in intensity and morphology to most other MHC hot spots. Crossovers at this hot spot are not obviously affected by a large insertion/deletion polymorphism near the hot spot. The second region of LD breakdown, within the DPB1 gene, shows an extremely low level of sperm crossover activity and does not contain a sperm crossover hot spot. These results highlight the complexity of LD patterns and the importance of experimentally verifying crossover hot spots.
DOI Link: 10.1016/j.ygeno.2005.03.011
ISSN: 0888-7543
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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