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Title: Signature of recent historical events in the European Y-chromosomal STR haplotype distribution.
Authors: Roewer, L
Croucher, PJ
Willuweit, S
Lu, TT
Kayser, M
Lessig, R
de Knijff P
Jobling, MA
Tyler-Smith, C
Krawczak, M
First Published: Mar-2005
Citation: HUM GENET, 2005, 116 (4), pp. 279-291
Abstract: Previous studies of human Y-chromosomal single-nucleotide polymorphisms (Y-SNPs) established a link between the extant Y-SNP haplogroup distribution and the prehistoric demography of Europe. By contrast, our analysis of seven rapidly evolving Y-chromosomal short tandem repeat loci (Y-STRs) in over 12,700 samples from 91 different locations in Europe reveals a signature of more recent historic events, not previously detected by other genetic markers. Cluster analysis based upon molecular variance yields two clearly identifiable sub-clusters of Western and Eastern European Y-STR haplotypes, and a diverse transition zone in central Europe, where haplotype spectra change more rapidly with longitude than with latitude. This and other observed patterns of Y-STR similarity may plausibly be related to particular historical incidents, including, for example, the expansion of the Franconian and Ottoman Empires. We conclude that Y-STRs may be capable of resolving male genealogies to an unparalleled degree and could therefore provide a useful means to study local population structure and recent demographic history.
DOI Link: 10.1007/s00439-004-1201-z
ISSN: 0340-6717
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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