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Title: Psoriasis is associated with increased beta-defensin genomic copy number.
Authors: Hollox, EJ
Huffmeier, U
Zeeuwen, PL
Palla, R
Lascorz, J
Rodijk-Olthuis, D
van de Kerkhof PC
Traupe, H
de Jongh G
den Heijer M
Reis, A
Armour, JA
Schalkwijk, J
First Published: Jan-2008
Citation: NAT GENET, 2008, 40 (1), pp. 23-25
Abstract: Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis.
DOI Link: 10.1038/ng.2007.48
eISSN: 1546-1718
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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