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Title: Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin.
Authors: Jansen, P. A.
Rodijk-Olthuis, D.
Hollox, Edward J.
Kamsteeg, M.
Tjabringa, G. S.
de Jongh, G. J.
van Vlijmen-Willems, I. M.
Bergboer, J. G.
van Rossum, M. M.
de Jong, E. M.
den Heijer, M.
Evers, A. W.
Bergers, M.
Armour, J. A.
Zeeuwen, P. L.
Schalkwijk, J.
First Published: 2009
Citation: PLoS ONE, 2009, 4 (3), pp. e4725-e4725
Abstract: Previous studies have extensively documented antimicrobial and chemotactic activities of beta-defensins. Human beta-defensin-2 (hBD-2) is strongly expressed in lesional psoriatic epidermis, and recently we have shown that high beta-defensin genomic copy number is associated with psoriasis susceptibility. It is not known, however, if biologically and pathophysiologically relevant concentrations of hBD-2 protein are present in vivo, which could support an antimicrobial and proinflammatory role of beta-defensins in lesional psoriatic epidermis.
DOI Link: 10.1371/journal.pone.0004725
ISSN: 1932-6203
eISSN: 1932-6203
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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