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Title: Elevated mutation rates in the germ line of first- and second-generation offspring of irradiated male mice.
Authors: Barber, R
Plumb, MA
Boulton, E
Roux, I
Dubrova, YE
First Published: 14-May-2002
Citation: PROC NATL ACAD SCI U S A, 2002, 99 (10), pp. 6877-6882
Abstract: Mutation rates at two expanded simple tandem repeat loci were studied in the germ line of first- and second-generation offspring of inbred male CBA/H, C57BL/6, and BALB/c mice exposed to either high linear energy transfer fission neutrons or low linear energy transfer x-rays. Paternal CBA/H exposure to either x-rays or fission neutrons resulted in increased mutation rates in the germ line of two subsequent generations. Comparable transgenerational effects were observed also in neutron-irradiated C57BL/6 and x-irradiated BALB/c mice. The levels of spontaneous mutation rates and radiation-induced transgenerational instability varied between strains (BALB/c>CBA/H>C57BL/6). Pre- and postmeiotic paternal exposure resulted in similar increases in mutation rate in the germ line of both generations of CBA/H mice, which together with our previous results suggests that radiation-induced expanded simple tandem repeat instability is manifested in diploid cells after fertilization. The remarkable finding that radiation-induced germ-line instability persists for at least two generations raises important issues of risk evaluation in humans.
DOI Link: 10.1073/pnas.102015399
ISSN: 0027-8424
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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