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Title: Monitoring spontaneous and induced human mutation by RAPD-PCR: a response to Weinberg et al. (2001).
Authors: Jeffreys, AJ
Dubrova, YE
First Published: 7-Dec-2001
Citation: PROC BIOL SCI, 2001, 268 (1484), pp. 2493-2494
Abstract: Weinberg et al. (2001, Proc. R. Soc. Lond. B 268, 1001-1005) have recently reported a major increase in mutation rate in the children of Chernobyl liquidators as a result of their fathers' exposure to ionizing radiation. If correct, this would provide dramatic evidence for radiation-induced mutation in humans, and would raise major concerns over the genetic effects of radiation. However, mutants were mainly detected using random amplified polymorphic DNA-PCR, an unreliable technology. These mutants were not validated and had no obvious molecular basis. They may, instead, have arisen as PCR artefacts or through non-paternity or sample mix-up. Unless these mutants can be validated, we recommend that Weinberg et al. withdraw their remarkable claims.
DOI Link: 10.1098/rspb.2001.1834
ISSN: 0962-8452
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Genetics

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