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Title: PERK in the life and death of the pancreatic beta-cell.
Authors: Herbert, TP
First Published: Nov-2007
Citation: BIOCHEM SOC TRANS, 2007, 35 (Pt 5), pp. 1205-1207
Abstract: To ensure cellular survival to ER (endoplasmic reticulum) stress, PERK [PKR (double-stranded-RNA-dependent protein kinase)-like ER kinase], an ER transmembrane kinase, is activated as part of the unfolded protein response. PERK is highly expressed in pancreatic beta-cells and is essential in the beta-cell's development, differentiation and function. However, chronic activation of PERK can induce cell death, and its activation has been implicated in both Type 1 and Type 2 diabetes. This short review aims to provide an insight into our current understanding of the role of PERK in the life and death of the beta-cell.
DOI Link: 10.1042/BST0351205
ISSN: 0300-5127
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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