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Title: Plasmin-mediated degradation of laminin gamma-1 is critical for ethanol-induced neurodegeneration.
Authors: Skrzypiec, AE
Maiya, R
Chen, Z
Pawlak, R
Strickland, S
First Published: 15-Oct-2009
Citation: BIOL PSYCHIATRY, 2009, 66 (8), pp. 785-794
Abstract: Alcoholism may result in severe neurological deficits and cognitive impairments. Many of the central effects of ethanol (EtOH) can be explained by upregulation of N-methyl-D-aspartate (NMDA) and downregulation of gamma-aminobutyric acid (GABA) A receptors (GABAA) in response to long-term EtOH consumption. Abrupt ethanol withdrawal (EW) may result in neuronal hyperexcitability leading to hallucinations, seizures, neurodegeneration, and sometimes death.
DOI Link: 10.1016/j.biopsych.2009.05.021
eISSN: 1873-2402
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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