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|Title:||Plasmin-mediated degradation of laminin gamma-1 is critical for ethanol-induced neurodegeneration.|
|Citation:||BIOL PSYCHIATRY, 2009, 66 (8), pp. 785-794|
|Abstract:||Alcoholism may result in severe neurological deficits and cognitive impairments. Many of the central effects of ethanol (EtOH) can be explained by upregulation of N-methyl-D-aspartate (NMDA) and downregulation of gamma-aminobutyric acid (GABA) A receptors (GABAA) in response to long-term EtOH consumption. Abrupt ethanol withdrawal (EW) may result in neuronal hyperexcitability leading to hallucinations, seizures, neurodegeneration, and sometimes death.|
|Appears in Collections:||Published Articles, Dept. of Cell Physiology and Pharmacology|
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