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Title: Endothelin-I and angiotensin II inhibit arterial voltage-gated K+ channels through different protein kinase C isoenzymes.
Authors: Rainbow, RD
Norman, RI
Everitt, DE
Brignell, JL
Davies, NW
Standen, NB
First Published: 1-Aug-2009
Citation: CARDIOVASC RES, 2009, 83 (3), pp. 493-500
Abstract: Voltage-gated K+ (Kv) channels of arterial smooth muscle (ASM) modulate arterial tone and are inhibited by vasoconstrictors through protein kinase C (PKC). We aimed to determine whether endothelin-1 (ET-1) and angiotensin II (AngII), which cause similar inhibition of Kv, use the same signalling pathway and PKC isoenzyme to exert their effects on Kv and to compare the involvement of PKC isoenzymes in contractile responses to these agents.
DOI Link: 10.1093/cvr/cvp143
eISSN: 1755-3245
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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