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Title: Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2.
Authors: Morris, GE
Nelson, CP
Standen, NB
Challiss, RA
Willets, JM
First Published: 1-Feb-2010
Citation: CARDIOVASC RES, 2010, 85 (3), pp. 424-433
Abstract: Prolonged endothelin (ET) receptor signalling causes vasoconstriction and can lead to hypertension, vascular smooth muscle hypertrophy, and hyperplasia. Usually, G protein-coupled receptor signalling is negatively regulated by G protein-coupled receptor kinases (GRKs), preventing prolonged or inappropriate signalling. This study investigated whether GRKs regulate ET receptor contractile signalling in adult Wistar rat mesenteric arterial smooth muscle cells (MSMCs).
DOI Link: 10.1093/cvr/cvp310
eISSN: 1755-3245
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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