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|Title:||Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2.|
|Citation:||CARDIOVASC RES, 2010, 85 (3), pp. 424-433|
|Abstract:||Prolonged endothelin (ET) receptor signalling causes vasoconstriction and can lead to hypertension, vascular smooth muscle hypertrophy, and hyperplasia. Usually, G protein-coupled receptor signalling is negatively regulated by G protein-coupled receptor kinases (GRKs), preventing prolonged or inappropriate signalling. This study investigated whether GRKs regulate ET receptor contractile signalling in adult Wistar rat mesenteric arterial smooth muscle cells (MSMCs).|
|Appears in Collections:||Published Articles, Dept. of Cell Physiology and Pharmacology|
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