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Title: Comparative pharmacology of guinea pig cardiac myocyte and cloned hERG (I(Kr)) channel.
Authors: Davie, C
Pierre-Valentin, J
Pollard, C
Standen, N
Mitcheson, J
Alexander, P
Thong, B
First Published: Nov-2004
Citation: J CARDIOVASC ELECTROPHYSIOL, 2004, 15 (11), pp. 1302-1309
Abstract: This study used whole-cell, patch clamp techniques on isolated guinea pig ventricular myocytes and HEK293 cells expressing cloned human ether-a-go-go-related gene (hERG) to examine the action of drugs causing QT interval prolongation and torsades de pointes (TdP) in man. Similarities and important differences in drug actions on cardiac myocytes and cloned hERG I(Kr) channels were established. Qualitative actions of the drugs on cardiac myocytes corresponded with results obtained from Purkinje fibers and measurement of QT interval prolongation in animal and human telemetry studies.
DOI Link: 10.1046/j.1540-8167.2004.04099.x
ISSN: 1045-3873
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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