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|Title:||Can optical recordings of membrane potential be used to screen for drug-induced action potential prolongation in single cardiac myocytes?|
|Citation:||J PHARMACOL TOXICOL METHODS, 2006, 54 (2), pp. 173-182|
|Abstract:||Potential-sensitive dyes have primarily been used to optically record action potentials (APs) in whole heart tissue. Using these dyes to record drug-induced changes in AP morphology of isolated cardiac myocytes could provide an opportunity to develop medium throughout assays for the pharmaceutical industry. Ideally, this requires that the dye has a consistent and rapid response to membrane potential, is insensitive to movement, and does not itself affect AP morphology.|
|Appears in Collections:||Published Articles, Dept. of Cell Physiology and Pharmacology|
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