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Title: Contribution of P2Y(1) receptors to ADP signalling in mouse spinal cord cultures.
Authors: Atterbury-Thomas, AE
Leon, C
Gachet, C
Forsythe, ID
Evans, RJ
First Published: 25-Apr-2008
Citation: NEUROSCI LETT, 2008, 435 (3), pp. 190-193
Abstract: Mixed neuronal and glial cell spinal cord cultures from neonates express ADP sensitive P2Y(1,12&13) receptors. ADP (10microM) evoked increases in intracellular calcium that were essentially abolished by the P2Y(1) receptor antagonist MRS2179 (10microM), responses were also absent in preparations from P2Y(1) receptor deficient mice however UTP (100microM) evoked calcium rises were unaffected. ADP also evoked a robust increase in extracellular signal-regulated protein kinase (ERK) phosphorylation that was of similar magnitude in the cultures from wild type and P2Y(1) receptor deficient mice. These results suggest that ADP acts through P2Y(1) receptors to mediate an increase in intracellular calcium but not to stimulate ERK phosphorylation in the spinal cord.
DOI Link: 10.1016/j.neulet.2008.02.034
ISSN: 0304-3940
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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