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Title: Location, location, GPCR phosphorylation offers a mechanism for cell-type-specific signalling.
Authors: Tobin, AB
Butcher, AJ
Kong, KC
First Published: Aug-2008
Citation: TRENDS PHARMACOL SCI, 2008, 29 (8), pp. 413-420
Abstract: It is now established that most of the approximately 800 G-protein-coupled receptors (GPCRs) are regulated by phosphorylation in a process that results in the recruitment of arrestins, leading to receptor desensitization and the activation of arrestin-dependent processes. This generalized view of GPCR regulation, however, does not provide an adequate mechanism for the control of tissue-specific GPCR signalling. Here, we review the evidence that GPCR phosphorylation is, in fact, a flexible and dynamic regulatory process in which GPCRs are phosphorylated in a unique manner that is associated with the cell type in which the receptor is expressed. In this scenario, phosphorylation offers a mechanism of regulating the signalling outcome of GPCRs that can be tailored to meet a specific physiological role.
DOI Link: 10.1016/
ISSN: 0165-6147
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cell Physiology and Pharmacology

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