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Title: Aberrant processing of oxidative DNA damage in systemic lupus erythematosus.
Authors: Evans, MD
Cooke, MS
Akil, M
Samanta, A
Lunec, J
First Published: 14-Jul-2000
Citation: BIOCHEM BIOPHYS RES COMMUN, 2000, 273 (3), pp. 894-898
Abstract: Defective DNA damage processing has been reported in systemic lupus erythematosus (SLE). Vitamin C may modulate formation/removal of the oxidative DNA lesion 8-oxo-2'-deoxyguanosine (8-oxodG). Baseline levels of 8-oxodG measured in SLE serum, urine and PBMC DNA did not differ significantly from healthy subjects. In contrast to healthy subjects, no significant decrease in PBMC 8-oxodG or increase in urinary 8-oxodG was noted in vitamin C supplemented SLE patients. A significant, although attenuated, increase in serum 8-oxodG was detected in SLE patients, compared to healthy subjects. These data support putative abnormalities in the repair/processing of 8-oxodG in SLE.
DOI Link: 10.1006/bbrc.2000.3078
ISSN: 0006-291X
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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