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|Title:||Aberrant processing of oxidative DNA damage in systemic lupus erythematosus.|
|Citation:||BIOCHEM BIOPHYS RES COMMUN, 2000, 273 (3), pp. 894-898|
|Abstract:||Defective DNA damage processing has been reported in systemic lupus erythematosus (SLE). Vitamin C may modulate formation/removal of the oxidative DNA lesion 8-oxo-2'-deoxyguanosine (8-oxodG). Baseline levels of 8-oxodG measured in SLE serum, urine and PBMC DNA did not differ significantly from healthy subjects. In contrast to healthy subjects, no significant decrease in PBMC 8-oxodG or increase in urinary 8-oxodG was noted in vitamin C supplemented SLE patients. A significant, although attenuated, increase in serum 8-oxodG was detected in SLE patients, compared to healthy subjects. These data support putative abnormalities in the repair/processing of 8-oxodG in SLE.|
|Appears in Collections:||Published Articles, Dept. of Cancer Studies and Molecular Medicine|
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