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Title: Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations.
Authors: Pollard, PJ
El-Bahrawy, M
Poulsom, R
Elia, G
Killick, P
Kelly, G
Hunt, T
Jeffery, R
Seedhar, P
Barwell, J
Latif, F
Gleeson, MJ
Hodgson, SV
Stamp, GW
Tomlinson, IP
Maher, ER
First Published: Nov-2006
Citation: J CLIN ENDOCRINOL METAB, 2006, 91 (11), pp. 4593-4598
Abstract: Activation of the hypoxia-inducible transcription factors HIF-1 and HIF-2 and a HIF-independent defect in developmental apoptosis have been implicated in the pathogenesis of pheochromocytoma (PCC) associated with VHL, SDHB, and SDHD mutations.
DOI Link: 10.1210/jc.2006-0920
ISSN: 0021-972X
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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