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|Title:||Effects of the potential chemopreventive agent DMU-135 on adenoma development in the ApcMin+ mouse.|
|Citation:||INVEST NEW DRUGS, 2006, 24 (6), pp. 459-464|
|Abstract:||DMU-135 (3,4-Methylenedioxy-3',4',5'-trimethoxy chalcone) is a novel anticancer prodrug designed to be activated into a potent tyrosine kinase inhibitor by the tumour selective enzyme activity of the cytochrome P450 enzyme CYP1B1. CYP1B1 is selectively expressed in a wide variety of tumours including colon. The hypothesis was tested that DMU-135 would inhibit Apc(Min/+) mouse gastrointestinal adenoma formation. From 4-18 weeks of age animals received DMU-135 (0.2% w:w) in AIN93G diet. DMU-135 was well tolerated, induced no systemic side-effects and reduced adenoma multiplicity by 46 +/- 18.3% compared to controls (p < 0.001). Further characterisation of this promising chemopreventive agent is required.|
|Appears in Collections:||Published Articles, Dept. of Cancer Studies and Molecular Medicine|
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