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Title: Functional analysis of altered Tenascin isoform expression in breast cancer
Authors: Alcock, R. A.
Pringle, J. H.
Shaw, J. A.
Holliday, D. L.
Allen, M.
Walker, R. A.
Jones, J. L.
First Published: 1-Jan-2006
Publisher: BioMed Central
Citation: Breast Cancer Research, 2006, 8(Suppl 2):P20
Abstract: Background: Cellular interactions with the extracellular matrix (ECM) control many aspects of cell function. The complex ECM protein Tenascin-C (TN), which exists as multiple isoforms, is upregulated in breast cancer. We previously have identified a change in the TN isoform profile in breast cancer, with detection of two additional isoforms — TN16 and TN14/16 — not seen in normal breast [1]. The purpose of this study was to investigate directly the effects of these tumour-associated TNC isoforms on breast cancer cell behaviour.
DOI Link: 10.1186/bcr1575
ISSN: 1465-5411
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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