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Title: G protein-coupled receptor kinase 2 and arrestin2 regulate arterial smooth muscle P2Y-purinoceptor signalling.
Authors: Morris, GE
Nelson, CP
Everitt, D
Brighton, PJ
Standen, NB
Challiss, RA
Willets, JM
First Published: 1-Jan-2011
Citation: CARDIOVASC RES, 2011, 89 (1), pp. 193-203
Abstract: prolonged P2Y-receptor signalling can cause vasoconstriction leading to hypertension, vascular smooth muscle hypertrophy, and hyperplasia. G protein-coupled receptor signalling is negatively regulated by G protein-coupled receptor kinases (GRKs) and arrestin proteins, preventing prolonged or inappropriate signalling. This study investigates whether GRKs and arrestins regulate uridine 5'-triphosphate (UTP)-stimulated contractile signalling in adult Wistar rat mesenteric arterial smooth muscle cells (MSMCs).
DOI Link: 10.1093/cvr/cvq249
eISSN: 1755-3245
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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