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Title: Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone.
Authors: Verschoyle, RD
Greaves, P
Cai, H
Borkhardt, A
Broggini, M
D'Incalci, M
Riccio, E
Doppalapudi, R
Kapetanovic, IM
Steward, WP
Gescher, AJ
First Published: Jan-2006
Citation: CANCER CHEMOTHER PHARMACOL, 2006, 57 (1), pp. 1-6
Abstract: Naturally occurring flavonoids such as quercetin and genistein possess cancer chemopreventive properties in experimental models. However, adverse effects such as their mutagenicity confound their potential clinical usefulness. Furthermore in leukaemia cells some flavonoids cleave the breakpoint cluster region of the mixed lineage leukaemia (MLL) gene as a consequence of inhibition of topoisomerase II. The choice of flavonoids to be developed as cancer chemopreventive agents depends crucially on their safety. Here, we explored safety aspects of the novel flavone tricin, a constituent of rice bran and other grass species, which has recently been found to interfere with murine gastrointestinal carcinogenesis.
DOI Link: 10.1007/s00280-005-0039-y
ISSN: 0344-5704
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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