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|Title:||Longitudinal variance components models for systolic blood pressure, fitted using Gibbs sampling.|
|Authors:||Scurrah, Katrina J.|
Tobin, Martin D.
Burton, Paul R.
|Citation:||BMC Genetics, 2003, 4 Suppl 1, pp. S25-S25|
|Abstract:||This paper describes an analysis of systolic blood pressure (SBP) in the Genetic Analysis Workshop 13 (GAW13) simulated data. The main aim was to assess evidence for both general and specific genetic effects on the baseline blood pressure and on the rate of change (slope) of blood pressure with time. Generalized linear mixed models were fitted using Gibbs sampling in WinBUGS, and the additive polygenic random effects estimated using these models were then used as continuous phenotypes in a variance components linkage analysis. The first-stage analysis provided evidence for general genetic effects on both the baseline and slope of blood pressure, and the linkage analysis found evidence of several genes, again for both baseline and slope.|
|Rights:||© 2003 Scurrah et al; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Version of record: http://www.biomedcentral.com/1471-2156/4/S1/S25|
|Appears in Collections:||Published Articles, Dept. of Health Sciences|
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