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Title: The complexities of breast cancer desmoplasia
Authors: Walker, Rosemary A.
First Published: 1-Feb-2001
Publisher: Biomed Central
Citation: Breast Cancer Research, 2001, 3, pp.143-145
Abstract: The stromal, or ‘desmoplastic’, responses seen histologically in primary breast carcinomas can vary from being predominantly cellular (fibroblasts/myofibroblasts) with little collagen to being a dense acellular tissue. The mechanisms underlying the stromal response are complex; paracrine activation of myofibroblasts by growth factors is important but the contribution of cytokines/chemokines should not be ignored. A recent xenograft study has proposed that platelet-derived growth factor (PDGF) is the initiator of the desmoplastic response, but this has not been confirmed by (limited) analyses in vivo. Further studies are required to elaborate the mechanisms of the desmoplastic response, to determine its role in breast cancer progression and whether it is the same for all carcinomas.
ISSN: 1465-542X
Type: Article
Description: Also available via
Appears in Collections:Published Articles, Dept. of Cancer Studies and Molecular Medicine

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