Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/16513
Title: Searching for the right outcome? A systematic review and meta-analysis of controlled trials using carotid intima-media thickness or pulse wave velocity to infer antiatherogenic properties of thiazolidinediones.
Authors: Webb, DR
Davies, MJ
Gray, LJ
Abrams, KR
Srinivasan, B
Das, S
Taub, N
Lawrence, I
Sutton, S
Khunti, K
First Published: Feb-2010
Citation: DIABETES OBES METAB, 2010, 12 (2), pp. 124-132
Abstract: Recent meta-analyses cast doubt over purported beneficial effects of Peroxisome Proliferator Activated Receptor-Gamma (PPAR-gamma) receptor agonists. Thiazolidinedione (TZD) trials using surrogate outcomes to postulate an antiatherogenic paradigm have been criticised as misinformative. We conducted an independent systematic review and meta-analysis of controlled TZD studies incorporating carotid intima-media thickness (CIMT) or pulse wave velocity (PWV) as primary outcome measures. The aim was to provide an evidence-based overview of TZD intervention studies using markers prospectively linked to vascular outcome in type 2 diabetes.
DOI Link: 10.1111/j.1463-1326.2009.01122.x
eISSN: 1463-1326
Links: http://hdl.handle.net/2381/16513
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Health Sciences

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