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Title: Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations.
Authors: Tobin, MD
Kähönen, M
Braund, P
Nieminen, T
Hajat, C
Tomaszewski, M
Viik, J
Lehtinen, R
Ng, GA
Macfarlane, PW
Burton, PR
Lehtimäki, T
Samani, NJ
First Published: Oct-2008
Citation: INT J EPIDEMIOL, 2008, 37 (5), pp. 1132-1141
Abstract: A longer heart-rate corrected QT interval (QTc) is associated with increased risk of ventricular arrhythmias. Women have longer resting QTc and are more likely than men to develop drug-induced QT prolongation. Recent studies have shown association between resting QTc and a common variant (rs10494366) of the NOS1 regulator, NOS1AP. We investigated the association between rs10494366 in NOS1AP and QTc, and assessed gender-specific NOS1AP associations with QTc during rest and after exercise.
DOI Link: 10.1093/ije/dyn091
eISSN: 1464-3685
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Health Sciences

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