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Title: Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology.
Authors: Burton, PR
Hansell, AL
Fortier, I
Manolio, TA
Khoury, MJ
Little, J
Elliott, P
First Published: Feb-2009
Citation: INT J EPIDEMIOL, 2009, 38 (1), pp. 263-273
Abstract: Despite earlier doubts, a string of recent successes indicates that if sample sizes are large enough, it is possible-both in theory and in practice-to identify and replicate genetic associations with common complex diseases. But human genome epidemiology is expensive and, from a strategic perspective, it is still unclear what 'large enough' really means. This question has critical implications for governments, funding agencies, bioscientists and the tax-paying public. Difficult strategic decisions with imposing price tags and important opportunity costs must be taken.
DOI Link: 10.1093/ije/dyn147
eISSN: 1464-3685
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Health Sciences

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