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Title: The role of cytokine gene polymorphisms in the pathogenesis of abdominal aortic aneurysms: a case-control study.
Authors: Bown, MJ
Burton, PR
Horsburgh, T
Nicholson, ML
Bell, PR
Sayers, RD
First Published: May-2003
Citation: J VASC SURG, 2003, 37 (5), pp. 999-1005
Abstract: Cytokines are the primary mediators of inflammation and also influence matrix metalloproteinase expression, both of which are important in development of abdominal aortic aneurysm (AAA). A significant, but as yet unknown, familial factor contributes to the pathogenesis of AAA. Many cytokine genes contain polymorphic sites, some of which affect cytokine production in vitro. Cytokine gene polymorphisms may therefore influence the pathogenesis of AAA. The purpose of this study was to determine whether there is any association between cytokine gene polymorphisms and AAA.
DOI Link: 10.1067/mva.2003.174
ISSN: 0741-5214
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Health Sciences

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