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Title: The interleukin-10-1082 'A' allele and abdominal aortic aneurysms.
Authors: Bown, MJ
Lloyd, GM
Sandford, RM
Thompson, JR
London, NJ
Samani, NJ
Sayers, RD
First Published: Oct-2007
Citation: J VASC SURG, 2007, 46 (4), pp. 687-693
Abstract: Abdominal aortic aneurysms (AAA) are caused by inflammatory processes in the wall of the aorta resulting in degradation of structural proteins. This inflammatory process is mediated, in part, by cytokines, and interleukin-10 (IL-10) is a predominantly anti-inflammatory cytokine. A single nucleotide polymorphism in the promoter region of the IL-10 gene that affects transcription has been associated with AAA in a small study. The aim of this study was to determine whether this polymorphism is associated with AAA and also examine its effect on the growth of small AAA.
DOI Link: 10.1016/j.jvs.2007.06.025
ISSN: 0741-5214
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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