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Title: New susceptibility locus for coronary artery disease on chromosome 3q22.3.
Authors: Erdmann, J
Grosshennig, A
Braund, PS
König, IR
Hengstenberg, C
Hall, AS
Linsel-Nitschke, P
Kathiresan, S
Wright, B
Trégouët, DA
Cambien, F
Bruse, P
Aherrahrou, Z
Wagner, AK
Stark, K
Schwartz, SM
Salomaa, V
Elosua, R
Melander, O
Voight, BF
O'Donnell, CJ
Peltonen, L
Siscovick, DS
Altshuler, D
Merlini, PA
Peyvandi, F
Bernardinelli, L
Ardissino, D
Schillert, A
Blankenberg, S
Zeller, T
Wild, P
Schwarz, DF
Tiret, L
Perret, C
Schreiber, S
El Mokhtari NE
Schäfer, A
März, W
Renner, W
Bugert, P
Klüter, H
Schrezenmeir, J
Rubin, D
Ball, SG
Balmforth, AJ
Wichmann, HE
Meitinger, T
Fischer, M
Meisinger, C
Baumert, J
Peters, A
Ouwehand, WH
Italian, Atherosclerosis
and Vascular Biology Working Group
Myocardial Infarction Genetics Consortium
Wellcome Trust Case Control Consortium
Cardiogenics, Consortium
Deloukas, P
Thompson, JR
Ziegler, A
Samani, NJ
Schunkert, H
First Published: Mar-2009
Citation: NAT GENET, 2009, 41 (3), pp. 280-282
Abstract: We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
DOI Link: 10.1038/ng.307
eISSN: 1546-1718
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Health Sciences

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