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Title: Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
Authors: Trégouët, DA
König, IR
Erdmann, J
Munteanu, A
Braund, PS
Hall, AS
Grosshennig, A
Linsel-Nitschke, P
Perret, C
DeSuremain, M
Meitinger, T
Wright, BJ
Preuss, M
Balmforth, AJ
Ball, SG
Meisinger, C
Germain, C
Evans, A
Arveiler, D
Luc, G
Ruidavets, JB
Morrison, C
van der Harst P
Schreiber, S
Neureuther, K
Schäfer, A
Bugert, P
El Mokhtari NE
Schrezenmeir, J
Stark, K
Rubin, D
Wichmann, HE
Hengstenberg, C
Ouwehand, W
Wellcome Trust Case Control Consortium
Cardiogenics, Consortium
Ziegler, A
Tiret, L
Thompson, JR
Cambien, F
Schunkert, H
Samani, NJ
First Published: Mar-2009
Citation: NAT GENET, 2009, 41 (3), pp. 283-285
Abstract: We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.
DOI Link: 10.1038/ng.314
eISSN: 1546-1718
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Health Sciences

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