Please use this identifier to cite or link to this item:
|Title:||Common variants near TERC are associated with mean telomere length.|
van der Harst P
Mateo Leach I
de Boer RA
Wellcome Trust Case Control Consortium
van Veldhuisen DJ
van Gilst WH
|Citation:||NAT GENET, 2010, 42 (3), pp. 197-199|
|Abstract:||We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition.|
|Appears in Collections:||Published Articles, Dept. of Health Sciences|
Files in This Item:
There are no files associated with this item.
Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.