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Title: Common variants near TERC are associated with mean telomere length.
Authors: Codd, V
Mangino, M
van der Harst P
Braund, PS
Kaiser, M
Beveridge, AJ
Rafelt, S
Moore, J
Nelson, C
Soranzo, N
Zhai, G
Valdes, AM
Blackburn, H
Mateo Leach I
de Boer RA
Kimura, M
Aviv, A
Wellcome Trust Case Control Consortium
Goodall, AH
Ouwehand, W
van Veldhuisen DJ
van Gilst WH
Navis, G
Burton, PR
Tobin, MD
Hall, AS
Thompson, JR
Spector, T
Samani, NJ
First Published: Mar-2010
Citation: NAT GENET, 2010, 42 (3), pp. 197-199
Abstract: We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition.
DOI Link: 10.1038/ng.532
eISSN: 1546-1718
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Health Sciences

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