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Title: Anti-platelet effect of aspirin is substantially reduced after administration of heparin during carotid endarterectomy.
Authors: Webster, SE
Payne, DA
Jones, CI
Hayes, PD
Bell, PR
Goodall, AH
Naylor, AR
First Published: Sep-2004
Citation: J VASC SURG, 2004, 40 (3), pp. 463-468
Abstract: Aspirin therapy is usually continued throughout the perioperative period to reduce the risk for thromboembolic stroke and myocardial infarction after carotid endarterectomy (CEA). Aspirin irreversibly binds cyclooxygenase-1, thereby reducing platelet aggregation for the lifetime of each platelet. However, recent research from this unit has shown that aggregation in response to arachidonic acid increases significantly, but transiently, during CEA, which suggests that the anti-platelet effect of aspirin is temporarily reversed. The purpose of the current study was to determine when this phenomenon occurs and to identify the possible mechanisms involved.
DOI Link: 10.1016/j.jvs.2004.06.022
ISSN: 0741-5214
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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