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Title: Aortic aneurysms as a source of circulating interleukin-6.
Authors: Dawson, J
Cockerill, G
Choke, E
Loftus, I
Thompson, MM
First Published: Nov-2006
Citation: ANN N Y ACAD SCI, 2006, 1085, pp. 320-323
Abstract: In keeping with the inflammatory paradigm of abdominal aortic aneurysm (AAA) pathophysiology, in vitro studies suggest that aneurysms secrete the proinflammatory cytokine interleukin-6 (IL-6). Circulating IL-6 levels are higher in patients with AAA with elevated circulating IL-6 an independent risk factor for cardiovascular mortality. To investigate whether aneurysms secrete IL-6 into the circulation, arterial IL-6 was measured from within the aorta in three groups of patients undergoing endovascular procedures; 27 AAA, 10 thoracic aneurysms (TA), and 15 controls. Overall, IL-6 was higher in the aneurysm groups (P < 0.0008) with significant rises corresponding to positions downstream to the aneurysm in both AAA and TA. There were no significant differences in IL-6 with aortic position in the control group. These data support the hypothesis that aneurysms secrete IL-6 into the circulation and may account for the high cardiovascular mortality observed in patients with aneurysms.
DOI Link: 10.1196/annals.1383.009
ISSN: 0077-8923
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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