Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/17062
Title: Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Authors: Speliotes, EK
Willer, CJ
Berndt, SI
Monda, KL
Thorleifsson, G
Jackson, AU
Lango Allen H
Lindgren, CM
Luan, J
Mägi, R
Randall, JC
Vedantam, S
Winkler, TW
Qi, L
Workalemahu, T
Heid, IM
Steinthorsdottir, V
Stringham, HM
Weedon, MN
Wheeler, E
Wood, AR
Ferreira, T
Weyant, RJ
Segrè, AV
Estrada, K
Liang, L
Nemesh, J
Park, JH
Gustafsson, S
Kilpeläinen, TO
Yang, J
Bouatia-Naji, N
Esko, T
Feitosa, MF
Kutalik, Z
Mangino, M
Raychaudhuri, S
Scherag, A
Smith, AV
Welch, R
Zhao, JH
Aben, KK
Absher, DM
Amin, N
Dixon, AL
Fisher, E
Glazer, NL
Goddard, ME
Heard-Costa, NL
Hoesel, V
Hottenga, JJ
Johansson, A
Johnson, T
Ketkar, S
Lamina, C
Li, S
Moffatt, MF
Myers, RH
Narisu, N
Perry, JR
Peters, MJ
Preuss, M
Ripatti, S
Rivadeneira, F
Sandholt, C
Scott, LJ
Timpson, NJ
Tyrer, JP
van Wingerden S
Watanabe, RM
White, CC
Wiklund, F
Barlassina, C
Chasman, DI
Cooper, MN
Jansson, JO
Lawrence, RW
Pellikka, N
Prokopenko, I
Shi, J
Thiering, E
Alavere, H
Alibrandi, MT
Almgren, P
Arnold, AM
Aspelund, T
Atwood, LD
Balkau, B
Balmforth, AJ
Bennett, AJ
Ben-Shlomo, Y
Bergman, RN
Bergmann, S
Biebermann, H
Blakemore, AI
Boes, T
Bonnycastle, LL
Bornstein, SR
Brown, MJ
Buchanan, TA
Busonero, F
Campbell, H
Cappuccio, FP
Cavalcanti-Proença, C
Chen, YD
Chen, CM
Chines, PS
Clarke, R
Coin, L
Connell, J
Day, IN
den Heijer M
Duan, J
Ebrahim, S
Elliott, P
Elosua, R
Eiriksdottir, G
Erdos, MR
Eriksson, JG
Facheris, MF
Felix, SB
Fischer-Posovszky, P
Folsom, AR
Friedrich, N
Freimer, NB
Fu, M
Gaget, S
Gejman, PV
Geus, EJ
Gieger, C
Gjesing, AP
Goel, A
Goyette, P
Grallert, H
Grässler, J
Greenawalt, DM
Groves, CJ
Gudnason, V
Guiducci, C
Hartikainen, AL
Hassanali, N
Hall, AS
Havulinna, AS
Hayward, C
Heath, AC
Hengstenberg, C
Hicks, AA
Hinney, A
Hofman, A
Homuth, G
Hui, J
Igl, W
Iribarren, C
Isomaa, B
Jacobs, KB
Jarick, I
Jewell, E
John, U
Jørgensen, T
Jousilahti, P
Jula, A
Kaakinen, M
Kajantie, E
Kaplan, LM
Kathiresan, S
Kettunen, J
Kinnunen, L
Knowles, JW
Kolcic, I
König, IR
Koskinen, S
Kovacs, P
Kuusisto, J
Kraft, P
Kvaløy, K
Laitinen, J
Lantieri, O
Lanzani, C
Launer, LJ
Lecoeur, C
Lehtimäki, T
Lettre, G
Liu, J
Lokki, ML
Lorentzon, M
Luben, RN
Ludwig, B
MAGIC
Manunta, P
Marek, D
Marre, M
Martin, NG
McArdle, WL
McCarthy, A
McKnight, B
Meitinger, T
Melander, O
Meyre, D
Midthjell, K
Montgomery, GW
Morken, MA
Morris, AP
Mulic, R
Ngwa, JS
Nelis, M
Neville, MJ
Nyholt, DR
O'Donnell, CJ
O'Rahilly, S
Ong, KK
Oostra, B
Paré, G
Parker, AN
Perola, M
Pichler, I
Pietiläinen, KH
Platou, CG
Polasek, O
Pouta, A
Rafelt, S
Raitakari, O
Rayner, NW
Ridderstråle, M
Rief, W
Ruokonen, A
Robertson, NR
Rzehak, P
Salomaa, V
Sanders, AR
Sandhu, MS
Sanna, S
Saramies, J
Savolainen, MJ
Scherag, S
Schipf, S
Schreiber, S
Schunkert, H
Silander, K
Sinisalo, J
Siscovick, DS
Smit, JH
Soranzo, N
Sovio, U
Stephens, J
Surakka, I
Swift, AJ
Tammesoo, ML
Tardif, JC
Teder-Laving, M
Teslovich, TM
Thompson, JR
Thomson, B
Tönjes, A
Tuomi, T
van Meurs JB
van Ommen GJ
Vatin, V
Viikari, J
Visvikis-Siest, S
Vitart, V
Vogel, CI
Voight, BF
Waite, LL
Wallaschofski, H
Walters, GB
Widen, E
Wiegand, S
Wild, SH
Willemsen, G
Witte, DR
Witteman, JC
Xu, J
Zhang, Q
Zgaga, L
Ziegler, A
Zitting, P
Beilby, JP
Farooqi, IS
Hebebrand, J
Huikuri, HV
James, AL
Kähönen, M
Levinson, DF
Macciardi, F
Nieminen, MS
Ohlsson, C
Palmer, LJ
Ridker, PM
Stumvoll, M
Beckmann, JS
Boeing, H
Boerwinkle, E
Boomsma, DI
Caulfield, MJ
Chanock, SJ
Collins, FS
Cupples, LA
Smith, GD
Erdmann, J
Froguel, P
Grönberg, H
Gyllensten, U
Hall, P
Hansen, T
Harris, TB
Hattersley, AT
Hayes, RB
Heinrich, J
Hu, FB
Hveem, K
Illig, T
Jarvelin, MR
Kaprio, J
Karpe, F
Khaw, KT
Kiemeney, LA
Krude, H
Laakso, M
Lawlor, DA
Metspalu, A
Munroe, PB
Ouwehand, WH
Pedersen, O
Penninx, BW
Peters, A
Pramstaller, PP
Quertermous, T
Reinehr, T
Rissanen, A
Rudan, I
Samani, NJ
Schwarz, PE
Shuldiner, AR
Spector, TD
Tuomilehto, J
Uda, M
Uitterlinden, A
Valle, TT
Wabitsch, M
Waeber, G
Wareham, NJ
Watkins, H
Procardis, Consortium
Wilson, JF
Wright, AF
Zillikens, MC
Chatterjee, N
McCarroll, SA
Purcell, S
Schadt, EE
Visscher, PM
Assimes, TL
Borecki, IB
Deloukas, P
Fox, CS
Groop, LC
Haritunians, T
Hunter, DJ
Kaplan, RC
Mohlke, KL
O'Connell, JR
Peltonen, L
Schlessinger, D
Strachan, DP
van Duijn CM
Wichmann, HE
Frayling, TM
Thorsteinsdottir, U
Abecasis, GR
Barroso, I
Boehnke, M
Stefansson, K
North, KE
McCarthy, MI
Hirschhorn, JN
Ingelsson, E
Loos, RJ
First Published: Nov-2010
Citation: NAT GENET, 2010, 42 (11), pp. 937-948
Abstract: Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
DOI Link: 10.1038/ng.686
eISSN: 1546-1718
Links: http://hdl.handle.net/2381/17062
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

Files in This Item:
There are no files associated with this item.


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.