Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/17063
Title: Association analysis of IL-12B and IL-23R polymorphisms in myocardial infarction.
Authors: Mangino, M
Braund, P
Singh, R
Steeds, R
Stevens, S
Channer, KS
Samani, NJ
First Published: Jan-2008
Citation: J MOL MED (BERL), 2008, 86 (1), pp. 99-103
Abstract: The notion that coronary atherosclerosis and its most severe phenotype, myocardial infarction (MI), are chronic inflammatory diseases is supported by several lines of evidence. Interleukins (ILs) are important mediators and modulators of inflammation. Specific polymorphisms in the genes encoding subunits of IL-23 (IL-12B) and its receptor (IL-23R) have recently been consistently found to be associated with chronic immune-mediated diseases. In this study, we explored the hypothesis that these variants also affect the risk of MI. We conducted a case-control association study on a cohort of 738 British Caucasian MI patients and 716 population controls. We tested four variants (rs11209026, rs7517847, rs1343151, rs10889677) of IL-23R and the A1188C polymorphism (rs3212227) of IL-12B. There was no association of any IL-23R (rs11209026, p = 0.82; rs7517847, p = 0.87; rs1343151, p = 0.85; rs10889677, p = 0.48) or IL-12B (rs3212227, p = 0.32) polymorphisms with MI. Stratification for age, gender and other cardiovascular risk factors did not affect the findings. These results indicate that unlike other chronic inflammatory diseases, the examined variants are unlikely to be major contributors to the pathogenesis of MI.
DOI Link: 10.1007/s00109-007-0264-4
eISSN: 1432-1440
Links: http://hdl.handle.net/2381/17063
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

Files in This Item:
There are no files associated with this item.


Items in LRA are protected by copyright, with all rights reserved, unless otherwise indicated.