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Title: Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids.
Authors: Lam, PM
McDonald, J
Lambert, DG
First Published: May-2005
Citation: BR J ANAESTH, 2005, 94 (5), pp. 649-656
Abstract: TRPV1 is a ligand-gated ion channel whose activation by capsaicin increases intracellular Ca(2+) ([Ca(2+)](i)). TRPV1 and cannabinoid CB(1) receptor activation are capable of eliciting analgesia. In this study, using recombinant human (h) and rat (r) TRPV1 receptors expressed in HEK293 cells, we have performed a comparison of both TRPV1 species at 22 and 37 degrees C and compared endo- and exocannabinoid activity at both receptors.
DOI Link: 10.1093/bja/aei098
ISSN: 0007-0912
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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