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Title: Dual antiplatelet therapy prior to carotid endarterectomy reduces post-operative embolisation and thromboembolic events: post-operative transcranial Doppler monitoring is now unnecessary.
Authors: Sharpe, RY
Dennis, MJ
Nasim, A
McCarthy, MJ
Sayers, RD
London, NJ
Naylor, AR
First Published: Aug-2010
Citation: EUR J VASC ENDOVASC SURG, 2010, 40 (2), pp. 162-167
Abstract: Thrombotic stroke following carotid endarterectomy (CEA) is preceded by high-grade embolisation (detected using transcranial Doppler (TCD)) and can be prevented by incremental doses of Dextran. However, this strategy is labour intensive and Dextran manufacture has now ceased. A randomised trial has suggested that a single 75 mg dose of Clopidogrel (administered the night before surgery in addition to daily 75 mg Aspirin) significantly reduces post-CEA embolisation. We hypothesized that this model of dual antiplatelet therapy might significantly reduce the need for adjuvant Dextran therapy.
DOI Link: 10.1016/j.ejvs.2010.04.004
eISSN: 1532-2165
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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