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Title: Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
Authors: Lindgren, C. M.
Heid, I. M.
Randall, J. C.
Lamina, C.
Steinthorsdottir, V.
Qi, L.
Speliotes, E. K.
Thorleifsson, G.
Willer, C. J.
Herrera, B. M.
Jackson, A. U.
Grundy, S.
Erdos, M. R.
Estrada, K.
Ferrucci, L.
Fischer, G.
Forouhi, N. G.
Gieger, C.
Guiducci, C.
Hadley, D.
Hamsten, A.
Waeber, G.
Illig, T.
Isomaa, B.
Jacobs, L. C.
Zhang, W.
Jameson, K.
Jousilahti, P.
Karpe, F.
Wellcome Trust Case Control Consortium
Kuusisto, J.
Laitinen, J.
Silander, K.
Lathrop, G. M.
Lawlor, D. A.
Mangino, M.
McArdle, W. L.
Uda, M.
Meitinger, T.
Morken, M. A.
Morris, A. P.
Munroe, P.
Witteman, J. C.
Song, K.
Narisu, N.
Nordström, A.
Nordström, P.
Oostra, B. A.
Palmer, C. N.
Vollenweider, P.
Payne, F.
Peden, J. F.
Prokopenko, I.
Renström, F.
Yuan, X.
Ruokonen, A.
Zhang, C.
Salomaa, V.
Sandhu, M. S.
Scott, L. J.
Scuteri, A.
Stringham, H. M.
Swift, A. J.
Tuomi, T.
Wallace, C.
Walters, G. B.
Weedon, M. N.
Mohlke, K. L.
Caulfield, M. J.
Collins, F. S.
Davey Smith G.
Amin, N.
Day, I. N.
Franks, P. W.
Hattersley, A. T.
Lim, N.
Hu, F. B.
Jarvelin, M. R.
Thorsteinsdottir, U.
Kong, A.
Kooner, J. S.
Laakso, M.
Lakatta, E.
Loos, R. J.
Mooser, V.
Morris, A. D.
Peltonen, L.
Samani, Nilesh J.
Scheet, P.
Schlessinger, D.
Spector, T. D.
Strachan, D. P.
Tanaka, T.
Tuomilehto, J.
Uitterlinden, A. G.
Stefansson, K.
van Duijn C. M.
Wareham, N. J.
Hugh, Watkins
Procardis, Consortia
Wichmann, H. E.
Waterworth, D. M.
Soranzo, N.
Boehnke, M.
Deloukas, P.
Groop, L.
Hunter, D. J.
Frayling, T. M.
Abecasis, G. R.
Hirschhorn, J. N.
Barroso, I.
McCarthy, M. I.
Giant, Consortium
Holloway, J. W.
Aulchenko, Y. S.
Chambers, J. C.
Drong, A.
Havulinna, A. S.
Luan, J.
Lyon, H. N.
Rivadeneira, F.
Sanna, S.
Timpson, N. J.
Zillikens, M. C.
Grallert, H.
Zhao, J. H.
Almgren, P.
Bandinelli, S.
Bennett, A. J.
Hofman, A.
Bergman, R. N.
Bonnycastle, L. L.
Bumpstead, S. J.
Chanock, S. J.
Cherkas, L.
Groves, C. J.
Chines, P.
Coin, L.
Cooper, C.
Crawford, G.
Doering, A.
Holle, R.
Dominiczak, A.
Doney, A. S.
Ebrahim, S.
Elliott, P.
First Published: 26-Jun-2009
Publisher: Public Library of Science
Citation: PLoS Genetics, 2009, 5 (6), pp. e1000508-e1000508
Abstract: To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.
DOI Link: 10.1371/journal.pgen.1000508
ISSN: 1553-7390
eISSN: 1553-7404
Type: Journal Article
Rights: This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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