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Title: Glutamate receptor-mediated inhibition of L-glutamate efflux from cerebral cortex in vitro.
Authors: Hainsworth, AH
Nelson, RM
Lambert, DG
Green, AR
Webb, TE
First Published: 9-Oct-2006
Citation: BRAIN RES, 2006, 1114 (1), pp. 36-40
Abstract: We tested whether glutamate receptor ligands affect oxygen-glucose deprivation-evoked L-glutamate efflux from adult rat cerebrocortical prisms. The uncompetitive NMDA antagonist AR-R15896AR inhibited efflux (IC50 34 microM, 87% maximal inhibition). AMPA/kainate receptor blockade (NBQX, 100 microM) or Group II metabotropic glutamate receptor activation (DCG-IV, 10 microM) inhibited efflux (41%, 67% respectively) but Group I mGluR blockade (CPCCOEt/MPEP, 10 microM) was without effect. These data support a modulatory effect of glutamate receptors on L-glutamate efflux.
DOI Link: 10.1016/j.brainres.2006.07.038
ISSN: 0006-8993
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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