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Title: Increased angiogenesis at the site of abdominal aortic aneurysm rupture.
Authors: Choke, E
Cockerill, GW
Dawson, J
Wilson, RW
Jones, A
Loftus, IM
Thompson, MM
First Published: Nov-2006
Citation: ANN N Y ACAD SCI, 2006, 1085, pp. 315-319
Abstract: Abdominal aortic aneurysm (AAA) rupture is associated with elevated levels of matrix metalloproteinase (MMP). Medial neovascularization is a known characteristic of established AAAs and involves proteolytic degradation of extracellular matrix by MMPs to facilitate endothelial cell proliferation and migration. This study evaluated the extent of neovascularization in abdominal aortic aneurysm rupture. Results indicated upregulation of proangiogenic cytokines and increased medial neovascularization at the aneurysm rupture edge compared with paired aneurysm anterior sac. Further investigations into the role of angiogenesis in aneurysm rupture may open novel therapeutic avenues to prevent aneurysm rupture.
DOI Link: 10.1196/annals.1383.007
ISSN: 0077-8923
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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