Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/17383
Title: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Authors: Heid, IM
Jackson, AU
Randall, JC
Winkler, TW
Qi, L
Steinthorsdottir, V
Thorleifsson, G
Zillikens, MC
Speliotes, EK
Mägi, R
Workalemahu, T
White, CC
Bouatia-Naji, N
Harris, TB
Berndt, SI
Ingelsson, E
Willer, CJ
Weedon, MN
Luan, J
Vedantam, S
Esko, T
Kilpeläinen, TO
Kutalik, Z
Li, S
Monda, KL
Dixon, AL
Holmes, CC
Kaplan, LM
Liang, L
Min, JL
Moffatt, MF
Molony, C
Nicholson, G
Schadt, EE
Zondervan, KT
Feitosa, MF
Ferreira, T
Lango Allen H
Weyant, RJ
Wheeler, E
Wood, AR
MAGIC
Estrada, K
Goddard, ME
Lettre, G
Mangino, M
Nyholt, DR
Purcell, S
Smith, AV
Visscher, PM
Yang, J
McCarroll, SA
Nemesh, J
Voight, BF
Absher, D
Amin, N
Aspelund, T
Coin, L
Glazer, NL
Hayward, C
Heard-Costa, NL
Hottenga, JJ
Johansson, A
Johnson, T
Kaakinen, M
Kapur, K
Ketkar, S
Knowles, JW
Kraft, P
Kraja, AT
Lamina, C
Leitzmann, MF
McKnight, B
Morris, AP
Ong, KK
Perry, JR
Peters, MJ
Polasek, O
Prokopenko, I
Rayner, NW
Ripatti, S
Rivadeneira, F
Robertson, NR
Sanna, S
Sovio, U
Surakka, I
Teumer, A
van Wingerden S
Vitart, V
Zhao, JH
Cavalcanti-Proença, C
Chines, PS
Fisher, E
Kulzer, JR
Lecoeur, C
Narisu, N
Sandholt, C
Scott, LJ
Silander, K
Stark, K
Tammesoo, ML
Teslovich, TM
Timpson, NJ
Watanabe, RM
Welch, R
Chasman, DI
Cooper, MN
Jansson, JO
Kettunen, J
Lawrence, RW
Pellikka, N
Perola, M
Vandenput, L
Alavere, H
Almgren, P
Atwood, LD
Bennett, AJ
Biffar, R
Bonnycastle, LL
Bornstein, SR
Buchanan, TA
Campbell, H
Day, IN
Dei, M
Dörr, M
Elliott, P
Erdos, MR
Eriksson, JG
Freimer, NB
Fu, M
Gaget, S
Geus, EJ
Gjesing, AP
Grallert, H
Grässler, J
Groves, CJ
Guiducci, C
Hartikainen, AL
Hassanali, N
Havulinna, AS
Herzig, KH
Hicks, AA
Hui, J
Igl, W
Jousilahti, P
Jula, A
Kajantie, E
Kinnunen, L
Kolcic, I
Koskinen, S
Kovacs, P
Kroemer, HK
Krzelj, V
Kuusisto, J
Kvaloy, K
Laitinen, J
Lantieri, O
Lathrop, GM
Lokki, ML
Luben, RN
Ludwig, B
McArdle, WL
McCarthy, A
Morken, MA
Nelis, M
Neville, MJ
Paré, G
Parker, AN
Peden, JF
Pichler, I
Pietiläinen, KH
Platou, CG
Pouta, A
Ridderstråle, M
Samani, NJ
Saramies, J
Sinisalo, J
Smit, JH
Strawbridge, RJ
Stringham, HM
Swift, AJ
Teder-Laving, M
Thomson, B
Usala, G
van Meurs JB
van Ommen GJ
Vatin, V
Volpato, CB
Wallaschofski, H
Walters, GB
Widen, E
Wild, SH
Willemsen, G
Witte, DR
Zgaga, L
Zitting, P
Beilby, JP
James, AL
Kähönen, M
Lehtimäki, T
Nieminen, MS
Ohlsson, C
Palmer, LJ
Raitakari, O
Ridker, PM
Stumvoll, M
Tönjes, A
Viikari, J
Balkau, B
Ben-Shlomo, Y
Bergman, RN
Boeing, H
Smith, GD
Ebrahim, S
Froguel, P
Hansen, T
Hengstenberg, C
Hveem, K
Isomaa, B
Jørgensen, T
Karpe, F
Khaw, KT
Laakso, M
Lawlor, DA
Marre, M
Meitinger, T
Metspalu, A
Midthjell, K
Pedersen, O
Salomaa, V
Schwarz, PE
Tuomi, T
Tuomilehto, J
Valle, TT
Wareham, NJ
Arnold, AM
Beckmann, JS
Bergmann, S
Boerwinkle, E
Boomsma, DI
Caulfield, MJ
Collins, FS
Eiriksdottir, G
Gudnason, V
Gyllensten, U
Hamsten, A
Hattersley, AT
Hofman, A
Hu, FB
Illig, T
Iribarren, C
Jarvelin, MR
Kao, WH
Kaprio, J
Launer, LJ
Munroe, PB
Oostra, B
Penninx, BW
Pramstaller, PP
Psaty, BM
Quertermous, T
Rissanen, A
Rudan, I
Shuldiner, AR
Soranzo, N
Spector, TD
Syvanen, AC
Uda, M
Uitterlinden, A
Völzke, H
Vollenweider, P
Wilson, JF
Witteman, JC
Wright, AF
Abecasis, GR
Boehnke, M
Borecki, IB
Deloukas, P
Frayling, TM
Groop, LC
Haritunians, T
Hunter, DJ
Kaplan, RC
North, KE
O'Connell, JR
Peltonen, L
Schlessinger, D
Strachan, DP
Hirschhorn, JN
Assimes, TL
Wichmann, HE
Thorsteinsdottir, U
van Duijn CM
Stefansson, K
Cupples, LA
Loos, RJ
Barroso, I
McCarthy, MI
Fox, CS
Mohlke, KL
Lindgren, CM
First Published: Nov-2010
Citation: NAT GENET, 2010, 42 (11), pp. 949-960
Abstract: Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
DOI Link: 10.1038/ng.685
eISSN: 1546-1718
Links: http://hdl.handle.net/2381/17383
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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