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|Title:||PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways|
|Authors:||Jones, C. I.|
Moraes, L. A.
Kaiser, W. J.
Gibbins, J. M.
Garner, S. F.
Ouwehand, W. H.
Ouwehand, W. H.
Goodall, A. H.
|Publisher:||Wiley, Federation of European Biochemical Societies|
|Citation:||FEBS Letters, 2009, 583 (22), pp. 3618-3624|
|Abstract:||Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits platelet response to collagen and may also inhibit two other major platelet agonists ADP and thrombin although this has been less well explored. We hypothesized that the combined effect of inhibiting these three platelet activating pathways may act to significantly inhibit thrombus formation. We demonstrate a negative relationship between PECAM-1 surface expression and platelet response to cross-linked collagen related peptide (CRP-XL) and ADP, and an inhibitory effect of PECAM-1 clustering on platelet response to CRP-XL, ADP and thrombin. This combined inhibition of multiple signaling pathways results in a marked reduction in thrombus formation.|
|Rights:||FEBS Letters 583 (2009) 0014-5793 ©2015 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License ( http://creativecommons.org/licenses/by-nc-nd/3.0/ ), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.|
|Appears in Collections:||Published Articles, Dept. of Cardiovascular Sciences|
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