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Title: Pharmacology of capsaicin-, anandamide-, and N-arachidonoyl-dopamine-evoked cell death in a homogeneous transient receptor potential vanilloid subtype 1 receptor population.
Authors: Davies, JW
Hainsworth, AH
Guerin, CJ
Lambert, DG
First Published: May-2010
Citation: BR J ANAESTH, 2010, 104 (5), pp. 596-602
Abstract: Transient receptor potential vanilloid subtype 1 (TRPV1) receptor is a primary pain-sensing relay at peripheral sensory nerve endings and is also widespread in the brain, where it is implicated in neurodegeneration. Previous studies of TRPV1 neurotoxicity have utilized heterogeneous receptor populations, non-selective ligands, or non-neuronal cell types. Here, we explored the pharmacology of TRPV1-induced cytotoxicity in a homogeneous, neurone-like cellular environment.
DOI Link: 10.1093/bja/aeq067
eISSN: 1471-6771
Type: Journal Article
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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