Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/17545
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dc.contributor.authorWiller, CJ-
dc.contributor.authorSpeliotes, EK-
dc.contributor.authorLoos, RJ-
dc.contributor.authorLi, S-
dc.contributor.authorLindgren, CM-
dc.contributor.authorHeid, IM-
dc.contributor.authorBerndt, SI-
dc.contributor.authorElliott, AL-
dc.contributor.authorJackson, AU-
dc.contributor.authorLamina, C-
dc.contributor.authorLettre, G-
dc.contributor.authorLim, N-
dc.contributor.authorLyon, HN-
dc.contributor.authorMcCarroll, SA-
dc.contributor.authorPapadakis, K-
dc.contributor.authorQi, L-
dc.contributor.authorRandall, JC-
dc.contributor.authorRoccasecca, RM-
dc.contributor.authorSanna, S-
dc.contributor.authorScheet, P-
dc.contributor.authorWeedon, MN-
dc.contributor.authorWheeler, E-
dc.contributor.authorZhao, JH-
dc.contributor.authorJacobs, LC-
dc.contributor.authorProkopenko, I-
dc.contributor.authorSoranzo, N-
dc.contributor.authorTanaka, T-
dc.contributor.authorTimpson, NJ-
dc.contributor.authorAlmgren, P-
dc.contributor.authorBennett, A-
dc.contributor.authorBergman, RN-
dc.contributor.authorBingham, SA-
dc.contributor.authorBonnycastle, LL-
dc.contributor.authorBrown, M-
dc.contributor.authorBurtt, NP-
dc.contributor.authorChines, P-
dc.contributor.authorCoin, L-
dc.contributor.authorCollins, FS-
dc.contributor.authorConnell, JM-
dc.contributor.authorCooper, C-
dc.contributor.authorSmith, GD-
dc.contributor.authorDennison, EM-
dc.contributor.authorDeodhar, P-
dc.contributor.authorElliott, P-
dc.contributor.authorErdos, MR-
dc.contributor.authorEstrada, K-
dc.contributor.authorEvans, DM-
dc.contributor.authorGianniny, L-
dc.contributor.authorGieger, C-
dc.contributor.authorGillson, CJ-
dc.contributor.authorGuiducci, C-
dc.contributor.authorHackett, R-
dc.contributor.authorHadley, D-
dc.contributor.authorHall, AS-
dc.contributor.authorHavulinna, AS-
dc.contributor.authorHebebrand, J-
dc.contributor.authorHofman, A-
dc.contributor.authorIsomaa, B-
dc.contributor.authorJacobs, KB-
dc.contributor.authorJohnson, T-
dc.contributor.authorJousilahti, P-
dc.contributor.authorJovanovic, Z-
dc.contributor.authorKhaw, KT-
dc.contributor.authorKraft, P-
dc.contributor.authorKuokkanen, M-
dc.contributor.authorKuusisto, J-
dc.contributor.authorLaitinen, J-
dc.contributor.authorLakatta, EG-
dc.contributor.authorLuan, J-
dc.contributor.authorLuben, RN-
dc.contributor.authorMangino, M-
dc.contributor.authorMcArdle, WL-
dc.contributor.authorMeitinger, T-
dc.contributor.authorMulas, A-
dc.contributor.authorMunroe, PB-
dc.contributor.authorNarisu, N-
dc.contributor.authorNess, AR-
dc.contributor.authorNorthstone, K-
dc.contributor.authorO'Rahilly, S-
dc.contributor.authorPurmann, C-
dc.contributor.authorRees, MG-
dc.contributor.authorRidderstråle, M-
dc.contributor.authorRing, SM-
dc.contributor.authorRivadeneira, F-
dc.contributor.authorRuokonen, A-
dc.contributor.authorSandhu, MS-
dc.contributor.authorSaramies, J-
dc.contributor.authorScott, LJ-
dc.contributor.authorScuteri, A-
dc.contributor.authorSilander, K-
dc.contributor.authorSims, MA-
dc.contributor.authorSong, K-
dc.contributor.authorStephens, J-
dc.contributor.authorStevens, S-
dc.contributor.authorStringham, HM-
dc.contributor.authorTung, YC-
dc.contributor.authorValle, TT-
dc.contributor.authorVan Duijn CM-
dc.contributor.authorVimaleswaran, KS-
dc.contributor.authorVollenweider, P-
dc.contributor.authorWaeber, G-
dc.contributor.authorWallace, C-
dc.contributor.authorWatanabe, RM-
dc.contributor.authorWaterworth, DM-
dc.contributor.authorWatkins, N-
dc.contributor.authorWellcome Trust Case Control Consortium-
dc.contributor.authorWitteman, JC-
dc.contributor.authorZeggini, E-
dc.contributor.authorZhai, G-
dc.contributor.authorZillikens, MC-
dc.contributor.authorAltshuler, D-
dc.contributor.authorCaulfield, MJ-
dc.contributor.authorChanock, SJ-
dc.contributor.authorFarooqi, IS-
dc.contributor.authorFerrucci, L-
dc.contributor.authorGuralnik, JM-
dc.contributor.authorHattersley, AT-
dc.contributor.authorHu, FB-
dc.contributor.authorJarvelin, MR-
dc.contributor.authorLaakso, M-
dc.contributor.authorMooser, V-
dc.contributor.authorOng, KK-
dc.contributor.authorOuwehand, WH-
dc.contributor.authorSalomaa, V-
dc.contributor.authorSamani, NJ-
dc.contributor.authorSpector, TD-
dc.contributor.authorTuomi, T-
dc.contributor.authorTuomilehto, J-
dc.contributor.authorUda, M-
dc.contributor.authorUitterlinden, AG-
dc.contributor.authorWareham, NJ-
dc.contributor.authorDeloukas, P-
dc.contributor.authorFrayling, TM-
dc.contributor.authorGroop, LC-
dc.contributor.authorHayes, RB-
dc.contributor.authorHunter, DJ-
dc.contributor.authorMohlke, KL-
dc.contributor.authorPeltonen, L-
dc.contributor.authorSchlessinger, D-
dc.contributor.authorStrachan, DP-
dc.contributor.authorWichmann, HE-
dc.contributor.authorMcCarthy, MI-
dc.contributor.authorBoehnke, M-
dc.contributor.authorBarroso, I-
dc.contributor.authorAbecasis, GR-
dc.contributor.authorHirschhorn, JN-
dc.contributor.authorGenetic Investigation of ANthropometric Traits Consortium-
dc.date.accessioned2012-10-24T09:04:05Z-
dc.date.available2012-10-24T09:04:05Z-
dc.date.issued2009-01-
dc.identifier.citationNAT GENET, 2009, 41 (1), pp. 25-34-
dc.identifier.urihttp://hdl.handle.net/2381/17545-
dc.description.abstractCommon variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.-
dc.formatmetadata-
dc.language.isoeng-
dc.sourcePubMed-
dc.source.urihttp://www.ncbi.nlm.nih.gov/pubmed/-
dc.subjectAlleles-
dc.subjectAnthropometry-
dc.subjectBody Mass Index-
dc.subjectBody Weight-
dc.subjectCentral Nervous System-
dc.subjectCohort Studies-
dc.subjectGene Dosage-
dc.subjectGenetic Predisposition to Disease-
dc.subjectGenome-Wide Association Study-
dc.subjectHumans-
dc.subjectMeta-Analysis as Topic-
dc.subjectObesity-
dc.subjectPolymorphism-
dc.subjectSingle Nucleotide-
dc.subjectQuantitative Trait Loci-
dc.subjectQuantitative Trait-
dc.subjectHeritable-
dc.titleSix new loci associated with body mass index highlight a neuronal influence on body weight regulation.-
dc.typeJournal Article-
dc.identifier.doi10.1038/ng.287-
dc.identifier.eissn1546-1718-
dc.identifier.piing.287-
dc.description.irispid21400-
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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