Please use this identifier to cite or link to this item: http://hdl.handle.net/2381/17547
Title: SLC2A9 is a high-capacity urate transporter in humans.
Authors: Caulfield, M. J.
Munroe, P. B.
O'Neill, D.
Witkowska, K.
Charchar, F. J.
Doblado, M.
Evans, S.
Eyheramendy, S.
Onipinla, A.
Howard, P.
Shaw-Hawkins, S.
Dobson, R. J.
Wallace, C.
Newhouse, S. J.
Brown, M.
Connell, J. M.
Dominiczak, A.
Farrall, M.
Lathrop, G. M.
Samani, Nilesh J.
Kumari, M.
Marmot, M.
Brunner, E.
Chambers, J.
Elliott, P.
Kooner, J.
Laan, M.
Org, E.
Veldre, G.
Viigimaa, M.
Cappuccio, F. P.
Ji, C.
Iacone, R.
Strazzullo, P.
Moley, K. H.
Cheeseman, C.
First Published: 7-Oct-2008
Citation: PLoS Medicine, 2008, 5 (10), pp. e197-e197
Abstract: Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have found common genetic variants of SLC2A9 to be associated with increased serum urate level and gout. The SLC2A9 gene encodes a facilitative glucose transporter, and it has two splice variants that are highly expressed in the proximal nephron, a key site for urate handling in the kidney. We investigated whether SLC2A9 is a functional urate transporter that contributes to the longstanding association between urate and blood pressure in man.
DOI Link: 10.1371/journal.pmed.0050197
ISSN: 1549-1277
eISSN: 1549-1676
Links: http://hdl.handle.net/2381/17547
http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0050197
Type: Journal Article
Rights: Copyright: © 2008 Caulfield et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Appears in Collections:Published Articles, Dept. of Cardiovascular Sciences

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