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|Title:||SLC2A9 is a high-capacity urate transporter in humans.|
|Authors:||Caulfield, M. J.|
Munroe, P. B.
Charchar, F. J.
Dobson, R. J.
Newhouse, S. J.
Connell, J. M.
Lathrop, G. M.
Samani, Nilesh J.
Cappuccio, F. P.
Moley, K. H.
|Citation:||PLoS Medicine, 2008, 5 (10), pp. e197-e197|
|Abstract:||Serum uric acid levels in humans are influenced by diet, cellular breakdown, and renal elimination, and correlate with blood pressure, metabolic syndrome, diabetes, gout, and cardiovascular disease. Recent genome-wide association scans have found common genetic variants of SLC2A9 to be associated with increased serum urate level and gout. The SLC2A9 gene encodes a facilitative glucose transporter, and it has two splice variants that are highly expressed in the proximal nephron, a key site for urate handling in the kidney. We investigated whether SLC2A9 is a functional urate transporter that contributes to the longstanding association between urate and blood pressure in man.|
|Rights:||Copyright: © 2008 Caulfield et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
|Appears in Collections:||Published Articles, Dept. of Cardiovascular Sciences|
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